Regenerative aesthetics aims to reestablish both the structure and function of aging tissue to restore the skin's youthful and healthy appearance

Published papers affirm the science and intend to create measurable parameters to guide clinical research and help define measurable, clinically relevant outcomes for aesthetic therapies that are truly regenerative

Merz Aesthetics, the world’s largest dedicated medical aesthetics business, announced today the publication of a Journal of Cosmetic Dermatology (JCD) Special Issue, providing new perspectives in the emerging area of regenerative aesthetics. The four published papers seek to establish a clear definition of regenerative aesthetics to begin creating consensus around this emerging area of aesthetic medicine, related to but distinct from regenerative medicine.

“Built on the principles of regenerative medicine, regenerative aesthetics seeks to restore the architecture and function of aging skin,” said Kate Goldie M.D., Medical Director of Clinic 77 Ltd and an author of one of the papers. Dr. Goldie also presented her paper during a Merz Aesthetics symposium at the 2023 Aesthetics & Anti-Aging Medicine World Congress in Monaco. “Through this new publication, we want to establish regenerative aesthetics as a distinct specialty with defined, measurable parameters so clinicians and researchers recognize the different treatment modalities that may profoundly change tissue and create real, vibrant and healthy tissue.”

For more than 30 years, medical aesthetics professionals have introduced a variety of compounds into the soft tissue to smooth out wrinkles and facial lines, and generally recreate a more youthful appearance. Over time, researchers have realized that some of these therapies, including products within the Merz Aesthetics portfolio, may greatly improve the tissue beyond the superficial surface shaping and smoothing.

About the Journal of Cosmetic Dermatology Special Issue
The four papers published today in the Journal of Cosmetic Dermatology are part of a special issue funded by Merz Aesthetics. The titles of these papers are included below:

  • The Evolving Field of Regenerative Aesthetics – authored by Dr. Kate Goldie, Clinic 77 Ltd, London, UK
  • Introducing Aesthetic Regenerative Scaffolds: An Immunological Perspective – authored by Dr. Niamh Corduff, Cosmetic Refinement Clinic, Geelong, Australia
  • Combining Topical Dermal Infused Exosomes with Injected Calcium Hydroxylapatite for Enhanced Tissue Biostimulation – authored by Dr. Gregory Chernoff, Department of Surgery, Ascension Hospital, Indianapolis, Indiana, USA
  • Catching the Aging Curve Early – authored by Dr. Daria Voropai, Kalea Clinic, Amsterdam, Netherlands

“At Merz Aesthetics, we have the most complete portfolio of products, including our line of fillers that offer unique tissue integration and stand out in terms of safety,” said Terri L. Phillips, M.D., Chief Medical Affairs Officer, Merz Aesthetics. “Currently, there is not a clear regulatory pathway to define therapies as regenerative aesthetics, so we’re thrilled to be at the forefront of helping to shape the future of this emerging area of medicine. Through continuing post-market research, we are working to better understand the approaches and combinations of treatments that may help us move toward truly repairing and restoring healthy, functioning tissue with the hopes of ultimately reversing aging.”

Understanding the Aging & Inflammatory Process
During the process of aging, key structural components of soft tissue decrease, including collagen and elastin. At the same time, tissue function is degraded impacting temperature control and integrity (firmness and elasticity), and at a molecular level, can affect cell-to-cell signaling and inflammatory processes.

In response to this deterioration and damage of soft tissue, the body triggers the immune system to repair tissue. As we age, the tissue repair process centers around the thickening or scarring of the tissue known as fibrosis. Anti-aging aesthetic medicines can influence this inflammatory pathway, either by healing through regeneration or by thickening and volumizing the skin through the inflammatory fibrotic process. Therefore, by understanding how biomaterial fillers influence the inflammatory pathway through healing via regeneration rather than fibrosis, researchers can develop broader strategies for restoring youthful skin beyond just stimulating collagen.

About Merz Aesthetics
Merz Aesthetics is a medical aesthetics business with a long history of empowering health care professionals, patients and employees to live every day with confidence. We aim to help people around the world look, feel and live like the best versions of themselves — however they define it. Clinically proven, its product portfolio includes injectables, devices and skin care treatments designed to meet each patient’s needs with high standards of safety and efficacy. Being family owned for more than 110 years, Merz Aesthetics is known for building unique connections with customers who feel like family. Merz Aesthetics’ global headquarters is in Raleigh, N.C., USA, with a commercial presence in 52 countries worldwide. It is also a part of Merz Group, which was founded in 1908 and is based in Frankfurt, Germany. Learn more at

Alison Brown
Global Corporate Communications
Merz Aesthetics
6501 Six Forks Road
Raleigh, NC 27615